Skip to main content

Table 3 Rate of subtelomeric tetherings of non-homologues in G1 of non-cycling cells.

From: Chromosome loops arising from intrachromosomal tethering of telomeres occur at high frequency in G1 (non-cycling) mitotic cells: Implications for telomere capture

Pairs of telomeres tested for tethering

No (%) of signal pairs tethered

95% confidence limits

1p telomere; 9q telomere*

7/109 (6.4)

2.6–12.8%

  1. Note: This is a control for chromosome specific p-q subtelomere signal pair tethering (Fig 2, Table 2). For this experiment the 1p subtelomere was labelled with spectrum orange and the 9q subtelomere with spectrum green. Subtelomere tethering between these non-homologues was not increased over chance expectation. The telomere pair* 1p and 9q were chosen because they represent one of the most frequent telomere translocations reported (Lisa Shaffer, personal communication 2004). Up to 10% of signal associations in a two colour matrix can be regarded as random (VYSIS guidelines for interphase FISH scoring). There was no departure from randomness for tethering with respect to these two pairs of non-homologous subtelomeres.