TY - JOUR AU - Hurley, L. H. PY - 2002 DA - 2002// TI - DNA and its associated processes as targets for cancer therapy JO - Nat Rev Cancer VL - 2 ID - Hurley2002 ER - TY - JOUR AU - Gieseg, M. A. AU - Matejovic, J. AU - Denny, W. A. PY - 1999 DA - 1999// TI - Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA JO - Anticancer Drug Des VL - 14 ID - Gieseg1999 ER - TY - JOUR AU - Herzig, M. C. AU - Trevino, A. V. AU - Arnett, B. AU - Woynarowski, J. M. PY - 1999 DA - 1999// TI - Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific JO - Biochemistry VL - 38 ID - Herzig1999 ER - TY - JOUR AU - Woynarowski, J. M. AU - Napier, C. AU - Trevino, A. V. AU - Arnett, B. PY - 2000 DA - 2000// TI - Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity JO - Biochemistry VL - 39 ID - Woynarowski2000 ER - TY - JOUR AU - Herzig, M. C. AU - Rodriguez, K. A. AU - Trevino, A. V. AU - Dziegielewski, J. AU - Arnett, B. AU - Hurley, L. AU - Woynarowski, J. M. PY - 2002 DA - 2002// TI - The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level JO - Biochemistry VL - 41 ID - Herzig2002 ER - TY - JOUR AU - Woynarowski, J. M. AU - Trevino, A. V. AU - Rodriguez, K. A. AU - Hardies, S. C. AU - Benham, C. J. PY - 2001 DA - 2001// TI - AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs JO - J Biol Chem VL - 276 ID - Woynarowski2001 ER - TY - JOUR AU - Dudouet, B. AU - Burnett, R. AU - Dickinson, L. A. AU - Wood, M. R. AU - Melander, C. AU - Belitsky, J. M. AU - Edelson, B. AU - Wurtz, N. AU - Briehn, C. AU - Dervan, P. B. AU - Gottesfeld, J. M. PY - 2003 DA - 2003// TI - Accessibility of nuclear chromatin by DNA binding polyamides JO - Chem Biol VL - 10 ID - Dudouet2003 ER - TY - JOUR AU - Abu-Daya, A. AU - Brown, P. M. AU - Fox, K. R. PY - 1995 DA - 1995// TI - DNA sequence preferences of several AT-selective minor groove binding ligands JO - Nucleic Acids Res VL - 23 ID - Abu-Daya1995 ER - TY - JOUR AU - Abu-Daya, A. AU - Fox, K. R. PY - 1997 DA - 1997// TI - Interaction of minor groove binding ligands with long AT tracts JO - Nucleic Acids Res VL - 25 ID - Abu-Daya1997 ER - TY - JOUR AU - Bremer, R. E. AU - Szewczyk, J. W. AU - Baird, E. E. AU - Dervan, P. B. PY - 2000 DA - 2000// TI - Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole JO - Bioorg Med Chem VL - 8 ID - Bremer2000 ER - TY - JOUR AU - Harshman, K. D. AU - Dervan, P. B. PY - 1985 DA - 1985// TI - Molecular recognition of B-DNA by Hoechst 33258 JO - Nucleic Acids Res VL - 13 ID - Harshman1985 ER - TY - JOUR AU - Schultz, P. G. AU - Dervan, P. B. PY - 1984 DA - 1984// TI - Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving JO - J Biomol Struct Dyn VL - 1 ID - Schultz1984 ER - TY - JOUR AU - Hurley, L. H. PY - 2001 DA - 2001// TI - Secondary DNA structures as molecular targets for cancer therapeutics JO - Biochem Soc Trans VL - 29 ID - Hurley2001 ER - TY - JOUR AU - Gniazdowski, M. AU - Denny, W. A. AU - Nelson, S. M. AU - Czyz, M. PY - 2003 DA - 2003// TI - Transcription factors as targets for DNA-interacting drugs JO - Curr Med Chem VL - 10 ID - Gniazdowski2003 ER - TY - JOUR AU - Woynarowski, J. M. PY - 2002 DA - 2002// TI - Targeting critical regions in genomic DNA with AT-specific anticancer drugs JO - Biochim Biophys Acta VL - 1587 ID - Woynarowski2002 ER - TY - JOUR AU - Reeves, R. AU - Beckerbauer, L. PY - 2001 DA - 2001// TI - HMGI/Y proteins: flexible regulators of transcription and chromatin structure JO - Biochim Biophys Acta VL - 1519 ID - Reeves2001 ER - TY - JOUR AU - Reeves, R. AU - Beckerbauer, L. M. PY - 2003 DA - 2003// TI - HMGA proteins as therapeutic drug targets JO - Prog Cell Cycle Res VL - 5 ID - Reeves2003 ER - TY - JOUR AU - Agresti, A. AU - Bianchi, M. E. PY - 2003 DA - 2003// TI - HMGB proteins and gene expression JO - Curr Opin Genet Dev VL - 13 ID - Agresti2003 ER - TY - JOUR AU - Catez, F. AU - Lim, J. H. AU - Hock, R. AU - Postnikov, Y. V. AU - Bustin, M. PY - 2003 DA - 2003// TI - HMGN dynamics and chromatin function JO - Biochem Cell Biol VL - 81 ID - Catez2003 ER - TY - JOUR AU - Thomas, J. O. PY - 2001 DA - 2001// TI - HMG1 and 2: architectural DNA-binding proteins JO - Biochem Soc Trans VL - 29 ID - Thomas2001 ER - TY - JOUR AU - Chiang, S. Y. AU - Welch, J. AU - Rauscher, F. J. ,. 3. r. d. AU - Beerman, T. A. PY - 1994 DA - 1994// TI - Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA JO - Biochemistry VL - 33 ID - Chiang1994 ER - TY - JOUR AU - Chow, C. S. AU - Whitehead, J. P. AU - Lippard, S. J. PY - 1994 DA - 1994// TI - HMG domain proteins induce sharp bends in cisplatin-modified DNA JO - Biochemistry VL - 33 ID - Chow1994 ER - TY - JOUR AU - Jung, Y. AU - Mikata, Y. AU - Lippard, S. J. PY - 2001 DA - 2001// TI - Kinetic studies of the TATA-binding protein interaction with cisplatin-modified DNA JO - J Biol Chem VL - 276 ID - Jung2001 ER - TY - JOUR AU - Jung, Y. AU - Lippard, S. J. PY - 2003 DA - 2003// TI - Nature of full-length HMGB1 binding to cisplatin-modified DNA JO - Biochemistry VL - 42 ID - Jung2003 ER - TY - JOUR AU - Welch, J. J. AU - Rauscher, F. J. ,. 3. r. d. AU - Beerman, T. A. PY - 1994 DA - 1994// TI - Targeting DNA-binding drugs to sequence-specific transcription factor.DNA complexes. Differential effects of intercalating and minor groove binding drugs JO - J Biol Chem VL - 269 ID - Welch1994 ER - TY - JOUR AU - Beckerbauer, L. AU - Tepe, J. J. AU - Cullison, J. AU - Reeves, R. AU - Williams, R. M. PY - 2000 DA - 2000// TI - FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo JO - Chem Biol VL - 7 ID - Beckerbauer2000 ER - TY - JOUR AU - Beckerbauer, L. AU - Tepe, J. J. AU - Eastman, R. A. AU - Mixter, P. F. AU - Williams, R. M. AU - Reeves, R. PY - 2002 DA - 2002// TI - Differential effects of FR900482 and FK317 on apoptosis, IL-2 gene expression, and induction of vascular leak syndrome JO - Chem Biol VL - 9 ID - Beckerbauer2002 ER - TY - JOUR AU - d'Adda di Fagagna, F. AU - Reaper, P. M. AU - Clay-Farrace, L. AU - Fiegler, H. AU - Carr, P. AU - Von Zglinicki, T. AU - Saretzki, G. AU - Carter, N. P. AU - Jackson, S. P. PY - 2003 DA - 2003// TI - A DNA damage checkpoint response in telomere-initiated senescence JO - Nature VL - 426 ID - d'Adda di Fagagna2003 ER - TY - JOUR AU - Weinmann, A. S. AU - Farnham, P. J. PY - 2002 DA - 2002// TI - Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation JO - Methods VL - 26 ID - Weinmann2002 ER - TY - JOUR AU - Wells, J. AU - Farnham, P. J. PY - 2002 DA - 2002// TI - Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation JO - Methods VL - 26 ID - Wells2002 ER - TY - JOUR AU - Hurley, L. H. AU - Wheelhouse, R. T. AU - Sun, D. AU - Kerwin, S. M. AU - Salazar, M. AU - Fedoroff, O. Y. AU - Han, F. X. AU - Han, H. AU - Izbicka, E. AU - Von Hoff, D. D. PY - 2000 DA - 2000// TI - G-quadruplexes as targets for drug design JO - Pharmacol Ther VL - 85 ID - Hurley2000 ER - TY - JOUR AU - Han, H. AU - Hurley, L. H. PY - 2000 DA - 2000// TI - G-quadruplex DNA: a potential target for anti-cancer drug design JO - Trends Pharmacol Sci VL - 21 ID - Han2000 ER - TY - JOUR AU - Siddiqui-Jain, A. AU - Grand, C. L. AU - Bearss, D. J. AU - Hurley, L. H. PY - 2002 DA - 2002// TI - Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription JO - Proc Natl Acad Sci U S A VL - 99 ID - Siddiqui-Jain2002 ER - TY - JOUR AU - Simonsson, T. AU - Pecinka, P. AU - Kubista, M. PY - 1998 DA - 1998// TI - DNA tetraplex formation in the control region of c-myc JO - Nucleic Acids Res VL - 26 ID - Simonsson1998 ER - TY - JOUR AU - Simonsson, T. AU - Pribylova, M. AU - Vorlickova, M. PY - 2000 DA - 2000// TI - A nuclease hypersensitive element in the human c-myc promoter adopts several distinct i-tetraplex structures JO - Biochem Biophys Res Commun VL - 278 ID - Simonsson2000 ER - TY - JOUR AU - Simonsson, T. AU - Sjoback, R. PY - 1999 DA - 1999// TI - DNA tetraplex formation studied with fluorescence resonance energy transfer JO - J Biol Chem VL - 274 ID - Simonsson1999 ER - TY - JOUR AU - Phillips, K. AU - Dauter, Z. AU - Murchie, A. I. AU - Lilley, D. M. AU - Luisi, B. PY - 1997 DA - 1997// TI - The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution JO - J Mol Biol VL - 273 ID - Phillips1997 ER - TY - JOUR AU - Brown, K. PY - 2002 DA - 2002// TI - Visualizing nuclear proteins together with transcribed and inactive genes in structurally preserved cells JO - Methods VL - 26 ID - Brown2002 ER - TY - JOUR AU - Brown, K. E. PY - 2003 DA - 2003// TI - Chromatin folding and gene expression: new tools to reveal the spatial organization of genes JO - Chromosome Res VL - 11 ID - Brown2003 ER - TY - JOUR AU - Brown, K. PY - 1999 DA - 1999// TI - Nuclear structure, gene expression and development JO - Crit Rev Eukaryot Gene Expr VL - 9 ID - Brown1999 ER - TY - JOUR AU - Dolnik, A. V. AU - Kuznetsova, I. S. AU - Voronin, A. P. AU - Podgornaya, O. I. PY - 2003 DA - 2003// TI - Telomere-binding TRF2/MTBP localization during mouse spermatogenesis and cell cycle of the mouse cells L929 JO - J Anti Aging Med VL - 6 ID - Dolnik2003 ER - TY - JOUR AU - Sidorova, J. M. AU - Breeden, L. L. PY - 2003 DA - 2003// TI - Precocious G1/S transitions and genomic instability: the origin connection JO - Mutat Res VL - 532 ID - Sidorova2003 ER - TY - JOUR AU - Barbour, L. AU - Xiao, W. PY - 2003 DA - 2003// TI - Regulation of alternative replication bypass pathways at stalled replication forks and its effects on genome stability: a yeast model JO - Mutat Res VL - 532 ID - Barbour2003 ER - TY - JOUR AU - Holmquist, G. P. AU - Maher, V. M. PY - 2002 DA - 2002// TI - The bypass of DNA lesions by DNA and RNA polymerases JO - Mutat Res VL - 510 ID - Holmquist2002 ER - TY - JOUR AU - Hu, W. AU - Kavanagh, J. J. PY - 2003 DA - 2003// TI - Anticancer therapy targeting the apoptotic pathway JO - Lancet Oncol VL - 4 ID - Hu2003 ER - TY - JOUR AU - Zhou, B. B. AU - Elledge, S. J. PY - 2000 DA - 2000// TI - The DNA damage response: putting checkpoints in perspective JO - Nature VL - 408 ID - Zhou2000 ER - TY - JOUR AU - Wang, Y. AU - Cortez, D. AU - Yazdi, P. AU - Neff, N. AU - Elledge, S. J. AU - Qin, J. PY - 2000 DA - 2000// TI - BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures JO - Genes Dev VL - 14 ID - Wang2000 ER - TY - JOUR AU - Fei, P. AU - El-Deiry, W. S. PY - 2003 DA - 2003// TI - P53 and radiation responses JO - Oncogene VL - 22 ID - Fei2003 ER - TY - JOUR AU - Iliakis, G. AU - Wang, Y. AU - Guan, J. AU - Wang, H. PY - 2003 DA - 2003// TI - DNA damage checkpoint control in cells exposed to ionizing radiation JO - Oncogene VL - 22 ID - Iliakis2003 ER - TY - JOUR AU - Goodarzi, A. A. AU - Block, W. D. AU - Lees-Miller, S. P. PY - 2003 DA - 2003// TI - The role of ATM and ATR in DNA damage-induced cell cycle control JO - Prog Cell Cycle Res VL - 5 ID - Goodarzi2003 ER - TY - JOUR AU - Kastan, M. B. AU - Lim, D. S. PY - 2000 DA - 2000// TI - The many substrates and functions of ATM JO - Nat Rev Mol Cell Biol VL - 1 ID - Kastan2000 ER - TY - JOUR AU - McGowan, C. H. PY - 2002 DA - 2002// TI - Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor JO - Bioessays VL - 24 ID - McGowan2002 ER - TY - JOUR AU - Bartek, J. AU - Falck, J. AU - Lukas, J. PY - 2001 DA - 2001// TI - CHK2 kinase--a busy messenger JO - Nat Rev Mol Cell Biol VL - 2 ID - Bartek2001 ER - TY - JOUR AU - Bartek, J. AU - Lukas, J. PY - 2003 DA - 2003// TI - Chk1 and Chk2 kinases in checkpoint control and cancer JO - Cancer Cell VL - 3 ID - Bartek2003 ER - TY - JOUR AU - Rhind, N. AU - Russell, P. PY - 1998 DA - 1998// TI - Mitotic DNA damage and replication checkpoints in yeast JO - Curr Opin Cell Biol VL - 10 ID - Rhind1998 ER - TY - JOUR AU - Lim, D. S. AU - Kim, S. T. AU - Xu, B. AU - Maser, R. S. AU - Lin, J. AU - Petrini, J. H. AU - Kastan, M. B. PY - 2000 DA - 2000// TI - ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway JO - Nature VL - 404 ID - Lim2000 ER - TY - JOUR AU - Kim, S. T. AU - Lim, D. S. AU - Canman, C. E. AU - Kastan, M. B. PY - 1999 DA - 1999// TI - Substrate specificities and identification of putative substrates of ATM kinase family members JO - J Biol Chem VL - 274 ID - Kim1999 ER - TY - JOUR AU - Cortez, D. AU - Wang, Y. AU - Qin, J. AU - Elledge, S. J. PY - 1999 DA - 1999// TI - Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks JO - Science VL - 286 ID - Cortez1999 ER - TY - JOUR AU - Zhong, Q. AU - Chen, C. F. AU - Li, S. AU - Chen, Y. AU - Wang, C. C. AU - Xiao, J. AU - Chen, P. L. AU - Sharp, Z. D. AU - Lee, W. H. PY - 1999 DA - 1999// TI - Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response JO - Science VL - 285 ID - Zhong1999 ER - TY - JOUR AU - Hansson, J. AU - Lewensohn, R. AU - Ringborg, U. AU - Nilsson, B. PY - 1987 DA - 1987// TI - Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells JO - Cancer Res VL - 47 ID - Hansson1987 ER - TY - JOUR AU - Pieper, R. O. AU - Futscher, B. W. AU - Erickson, L. C. PY - 1989 DA - 1989// TI - Transcription-terminating lesions induced by bifunctional alkylating agents in vitro JO - Carcinogenesis VL - 10 ID - Pieper1989 ER - TY - JOUR AU - Wang, A. L. AU - Tew, K. D. PY - 1985 DA - 1985// TI - Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards JO - Cancer Treat Rep VL - 69 ID - Wang1985 ER - TY - JOUR AU - Suzukake, K. AU - Vistica, B. P. AU - Vistica, D. T. PY - 1983 DA - 1983// TI - Dechlorination of L-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content JO - Biochem Pharmacol VL - 32 ID - Suzukake1983 ER - TY - JOUR AU - Brendel, M. AU - Ruhland, A. PY - 1984 DA - 1984// TI - Relationships between functionality and genetic toxicology of selected DNA-damaging agents JO - Mutat Res VL - 133 ID - Brendel1984 ER - TY - JOUR AU - Palmer, R. G. AU - Denman, A. M. PY - 1984 DA - 1984// TI - Malignancies induced by chlorambucil JO - Cancer Treat Rev VL - 11 ID - Palmer1984 ER - TY - JOUR AU - Schein, P. S. AU - O'Connell, M. J. AU - Blom, J. AU - Hubbard, S. AU - Magrath, I. T. AU - Bergevin, P. AU - Wiernik, P. H. AU - Ziegler, J. L. AU - DeVita, V. T. PY - 1974 DA - 1974// TI - Clinical antitumor activity and toxicity of streptozotocin (NSC-85998) JO - Cancer VL - 34 ID - Schein1974 ER - TY - JOUR AU - Cohen, G. L. AU - Falkson, C. I. PY - 1998 DA - 1998// TI - Current treatment options for malignant melanoma JO - Drugs VL - 55 ID - Cohen1998 ER - TY - JOUR AU - Friedman, H. S. AU - Kerby, T. AU - Calvert, H. PY - 2000 DA - 2000// TI - Temozolomide and treatment of malignant glioma JO - Clin Cancer Res VL - 6 ID - Friedman2000 ER - TY - JOUR AU - Bradner, W. T. PY - 2001 DA - 2001// TI - Mitomycin C: a clinical update JO - Cancer Treat Rev VL - 27 ID - Bradner2001 ER - TY - JOUR AU - Ramel, C. PY - 1997 DA - 1997// TI - Mini- and microsatellites JO - Environ Health Perspect VL - 105 Suppl 4 ID - Ramel1997 ER - TY - JOUR AU - Debrauwere, H. AU - Gendrel, C. G. AU - Lechat, S. AU - Dutreix, M. PY - 1997 DA - 1997// TI - Differences and similarities between various tandem repeat sequences: minisatellites and microsatellites JO - Biochimie VL - 79 ID - Debrauwere1997 ER - TY - JOUR AU - Jackson, J. A. AU - Trevino, A. V. AU - Herzig, M. C. AU - Herman, T. S. AU - Woynarowski, J. M. PY - 2003 DA - 2003// TI - Matrix attachment region (MAR) properties and abnormal expansion of AT island minisatellites in FRA16B fragile sites in leukemic CEM cells JO - Nucleic Acids Res VL - 31 ID - Jackson2003 ER - TY - JOUR AU - Hanka, L. J. AU - Dietz, A. AU - Gerpheide, S. A. AU - Kuentzel, S. L. AU - Martin, D. G. PY - 1978 DA - 1978// TI - CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism JO - J Antibiot (Tokyo) VL - 31 ID - Hanka1978 ER - TY - JOUR AU - Atwell, G. J. AU - Tercel, M. AU - Boyd, M. AU - Wilson, W. R. AU - Denny, W. A. PY - 1998 DA - 1998// TI - Synthesis and cytotoxicity of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbomyl]-1,2-dihydre-3H-bene[e]indole (amino-seco-CBI-TMI) and related 5-alkylamino analogues: new DNA minor groove alkylating agents. JO - J.Org. Chem VL - 63 ID - Atwell1998 ER - TY - JOUR AU - Reddy, B. S. AU - Sharma, S. K. AU - Lown, J. W. PY - 2001 DA - 2001// TI - Recent developments in sequence selective minor groove DNA effectors JO - Curr Med Chem VL - 8 ID - Reddy2001 ER - TY - JOUR AU - Woynarowski, J. M. AU - McHugh, M. M. AU - Gawron, L. S. AU - Beerman, T. A. PY - 1995 DA - 1995// TI - Effects of bizelesin (U-77779), a bifunctional alkylating minor groove agent, on genomic and simian virus 40 DNA JO - Biochemistry VL - 34 ID - Woynarowski1995 ER - TY - JOUR AU - McHugh, M. M. AU - Woynarowski, J. M. AU - Mitchell, M. A. AU - Gawron, L. S. AU - Weiland, K. L. AU - Beerman, T. A. PY - 1994 DA - 1994// TI - CC-1065 bonding to intracellular and purified SV40 DNA: site specificity and functional effects JO - Biochemistry VL - 33 ID - McHugh1994 ER - TY - JOUR AU - Cobuzzi, R. J. ,. J. r. AU - Burhans, W. C. AU - Beerman, T. A. PY - 1996 DA - 1996// TI - Inhibition of initiation of simian virus 40 DNA replication in infected BSC-1 cells by the DNA alkylating drug adozelesin JO - J Biol Chem VL - 271 ID - Cobuzzi1996 ER - TY - JOUR AU - Woynarowski, J. M. AU - Beerman, T. A. PY - 1997 DA - 1997// TI - Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells JO - Biochim Biophys Acta VL - 1353 ID - Woynarowski1997 ER - TY - JOUR AU - Weinberger, M. AU - Trabold, P. A. AU - Lu, M. AU - Sharma, K. AU - Huberman, J. A. AU - Burhans, W. C. PY - 1999 DA - 1999// TI - Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae JO - J Biol Chem VL - 274 ID - Weinberger1999 ER - TY - JOUR AU - McHugh, M. M. AU - Kuo, S. R. AU - Walsh-O'Beirne, M. H. AU - Liu, J. S. AU - Melendy, T. AU - Beerman, T. A. PY - 1999 DA - 1999// TI - Bizelesin, a bifunctional cyclopropylpyrroloindole alkylating agent, inhibits simian virus 40 replication in trans by induction of an inhibitor JO - Biochemistry VL - 38 ID - McHugh1999 ER - TY - JOUR AU - Wang, Y. AU - Beerman, T. A. AU - Kowalski, D. PY - 2001 DA - 2001// TI - Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants JO - Cancer Res VL - 61 ID - Wang2001 ER - TY - JOUR AU - Sun, D. AU - Hurley, L. H. PY - 1994 DA - 1994// TI - Binding of Sp1 to the 21-bp repeat region of SV40 DNA: effect of intrinsic and drug-induced DNA bending between GC boxes JO - Gene VL - 149 ID - Sun1994 ER - TY - JOUR AU - Cameron, L. AU - Thompson, A. S. PY - 2000 DA - 2000// TI - Determination of the structural role of the linking moieties in the DNA binding of adozelesin JO - Biochemistry VL - 39 ID - Cameron2000 ER - TY - JOUR AU - Black, A. R. AU - Black, J. D. AU - Azizkhan-Clifford, J. PY - 2001 DA - 2001// TI - Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer JO - J Cell Physiol VL - 188 ID - Black2001 ER - TY - JOUR AU - Dervan, P. B. AU - Edelson, B. S. PY - 2003 DA - 2003// TI - Recognition of the DNA minor groove by pyrrole-imidazole polyamides JO - Curr Opin Struct Biol VL - 13 ID - Dervan2003 ER - TY - JOUR AU - Gottesfeld, J. M. AU - Melander, C. AU - Suto, R. K. AU - Raviol, H. AU - Luger, K. AU - Dervan, P. B. PY - 2001 DA - 2001// TI - Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides JO - J Mol Biol VL - 309 ID - Gottesfeld2001 ER - TY - JOUR AU - Zimmer, C. AU - Wahnert, U. PY - 1986 DA - 1986// TI - Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material JO - Prog Biophys Mol Biol VL - 47 ID - Zimmer1986 ER - TY - JOUR AU - Ehley, J. A. AU - Melander, C. AU - Herman, D. AU - Baird, E. E. AU - Ferguson, H. A. AU - Goodrich, J. A. AU - Dervan, P. B. AU - Gottesfeld, J. M. PY - 2002 DA - 2002// TI - Promoter scanning for transcription inhibition with DNA-binding polyamides JO - Mol Cell Biol VL - 22 ID - Ehley2002 ER - TY - JOUR AU - Dickinson, L. A. AU - Trauger, J. W. AU - Baird, E. E. AU - Dervan, P. B. AU - Graves, B. J. AU - Gottesfeld, J. M. PY - 1999 DA - 1999// TI - Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappaB, and DNA by a designed DNA-binding ligand JO - J Biol Chem VL - 274 ID - Dickinson1999 ER - TY - JOUR AU - Wurtz, N. R. AU - Dervan, P. B. PY - 2000 DA - 2000// TI - Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates JO - Chem Biol VL - 7 ID - Wurtz2000 ER - TY - JOUR AU - Coull, J. J. AU - He, G. AU - Melander, C. AU - Rucker, V. C. AU - Dervan, P. B. AU - Margolis, D. M. PY - 2002 DA - 2002// TI - Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides JO - J Virol VL - 76 ID - Coull2002 ER - TY - JOUR AU - Wang, Y. D. AU - Dziegielewski, J. AU - Wurtz, N. R. AU - Dziegielewska, B. AU - Dervan, P. B. AU - Beerman, T. A. PY - 2003 DA - 2003// TI - DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate JO - Nucleic Acids Res VL - 31 ID - Wang2003 ER - TY - JOUR AU - Wang, Y. D. AU - Dziegielewski, J. AU - Chang, A. Y. AU - Dervan, P. B. AU - Beerman, T. A. PY - 2002 DA - 2002// TI - Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate JO - J Biol Chem VL - 277 ID - Wang2002 ER - TY - JOUR AU - D'Incalci, M. AU - Erba, E. AU - Damia, G. AU - Galliera, E. AU - Carrassa, L. AU - Marchini, S. AU - Mantovani, R. AU - Tognon, G. AU - Fruscio, R. AU - Jimeno, J. AU - Faircloth, G. T. PY - 2002 DA - 2002// TI - Unique features of the mode of action of ET-743 JO - Oncologist VL - 7 ID - D'Incalci2002 ER - TY - JOUR AU - Schwartsmann, G. AU - Da Rocha, A. B. AU - Mattei, J. AU - Lopes, R. PY - 2003 DA - 2003// TI - Marine-derived anticancer agents in clinical trials JO - Expert Opin Investig Drugs VL - 12 ID - Schwartsmann2003 ER - TY - JOUR AU - Pommier, Y. AU - Kohlhagen, G. AU - Bailly, C. AU - Waring, M. AU - Mazumder, A. AU - Kohn, K. W. PY - 1996 DA - 1996// TI - DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata JO - Biochemistry VL - 35 ID - Pommier1996 ER - TY - JOUR AU - Garcia-Nieto, R. AU - Manzanares, I. AU - Cuevas, C. AU - Gago, F. PY - 2000 DA - 2000// TI - Increased DNA binding specificity for antitumor ecteinascidin 743 through protein-DNA interactions? JO - J Med Chem VL - 43 ID - Garcia-Nieto2000 ER - TY - JOUR AU - Hurley, L. H. AU - Zewail-Foote, M. PY - 2001 DA - 2001// TI - The antitumor agent ecteinascidin 743: characterization of its covalent DNA adducts and chemical stability JO - Adv Exp Med Biol VL - 500 ID - Hurley2001 ER - TY - JOUR AU - Zewail-Foote, M. AU - Hurley, L. H. PY - 2001 DA - 2001// TI - Differential rates of reversibility of ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favored bonding sites JO - J Am Chem Soc VL - 123 ID - Zewail-Foote2001 ER - TY - JOUR AU - Zewail-Foote, M. AU - Hurley, L. H. PY - 1999 DA - 1999// TI - Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove JO - J Med Chem VL - 42 ID - Zewail-Foote1999 ER - TY - JOUR AU - Bonfanti, M. AU - La Valle, E. AU - Fernandez Sousa Faro, J. M. AU - Faircloth, G. AU - Caretti, G. AU - Mantovani, R. AU - D'Incalci, M. PY - 1999 DA - 1999// TI - Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA JO - Anticancer Drug Des VL - 14 ID - Bonfanti1999 ER - TY - JOUR AU - Jin, S. AU - Gorfajn, B. AU - Faircloth, G. AU - Scotto, K. W. PY - 2000 DA - 2000// TI - Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation JO - Proc Natl Acad Sci U S A VL - 97 ID - Jin2000 ER - TY - JOUR AU - Minuzzo, M. AU - Marchini, S. AU - Broggini, M. AU - Faircloth, G. AU - D'Incalci, M. AU - Mantovani, R. PY - 2000 DA - 2000// TI - Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743 JO - Proc Natl Acad Sci U S A VL - 97 ID - Minuzzo2000 ER - TY - JOUR AU - Friedman, D. AU - Hu, Z. AU - Kolb, E. A. AU - Gorfajn, B. AU - Scotto, K. W. PY - 2002 DA - 2002// TI - Ecteinascidin-743 inhibits activated but not constitutive transcription JO - Cancer Res VL - 62 ID - Friedman2002 ER - TY - JOUR AU - Martinez, E. J. AU - Owa, T. AU - Schreiber, S. L. AU - Corey, E. J. PY - 1999 DA - 1999// TI - Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743 JO - Proc Natl Acad Sci U S A VL - 96 ID - Martinez1999 ER - TY - JOUR AU - Martinez, E. J. AU - Corey, E. J. AU - Owa, T. PY - 2001 DA - 2001// TI - Antitumor activity- and gene expression-based profiling of ecteinascidin Et 743 and phthalascidin Pt 650 JO - Chem Biol VL - 8 ID - Martinez2001 ER - TY - JOUR AU - Adams, J. AU - Elliott, P. J. PY - 2000 DA - 2000// TI - New agents in cancer clinical trials JO - Oncogene VL - 19 ID - Adams2000 ER - TY - JOUR AU - Marco, E. AU - Garcia-Nieto, R. AU - Mendieta, J. AU - Manzanares, I. AU - Cuevas, C. AU - Gago, F. PY - 2002 DA - 2002// TI - A 3.(ET743)-DNA complex that both resembles an RNA-DNA hybrid and mimicks zinc finger-induced DNA structural distortions JO - J Med Chem VL - 45 ID - Marco2002 ER - TY - JOUR AU - Damia, G. AU - Silvestri, S. AU - Carrassa, L. AU - Filiberti, L. AU - Faircloth, G. T. AU - Liberi, G. AU - Foiani, M. AU - D'Incalci, M. PY - 2001 DA - 2001// TI - Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways JO - Int J Cancer VL - 92 ID - Damia2001 ER - TY - JOUR AU - Takebayashi, Y. AU - Pourquier, P. AU - Zimonjic, D. B. AU - Nakayama, K. AU - Emmert, S. AU - Ueda, T. AU - Urasaki, Y. AU - Kanzaki, A. AU - Akiyama, S. I. AU - Popescu, N. AU - Kraemer, K. H. AU - Pommier, Y. PY - 2001 DA - 2001// TI - Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair JO - Nat Med VL - 7 ID - Takebayashi2001 ER - TY - JOUR AU - Usdin, K. AU - Grabczyk, E. PY - 2000 DA - 2000// TI - DNA repeat expansions and human disease JO - Cell Mol Life Sci VL - 57 ID - Usdin2000 ER - TY - JOUR AU - Rhodes, D. AU - Fairall, L. AU - Simonsson, T. AU - Court, R. AU - Chapman, L. PY - 2002 DA - 2002// TI - Telomere architecture JO - EMBO Rep VL - 3 ID - Rhodes2002 ER - TY - JOUR AU - Rezler, E. M. AU - Bearss, D. J. AU - Hurley, L. H. PY - 2003 DA - 2003// TI - Telomere inhibition and telomere disruption as processes for drug targeting JO - Annu Rev Pharmacol Toxicol VL - 43 ID - Rezler2003 ER - TY - JOUR AU - Kanoh, J. AU - Ishikawa, F. PY - 2003 DA - 2003// TI - Composition and conservation of the telomeric complex JO - Cell Mol Life Sci VL - 60 ID - Kanoh2003 ER - TY - JOUR AU - Meeker, A. K. AU - De Marzo, A. M. PY - 2004 DA - 2004// TI - Recent advances in telomere biology: implications for human cancer JO - Curr Opin Oncol VL - 16 ID - Meeker2004 ER - TY - JOUR AU - Saretzki, G. PY - 2003 DA - 2003// TI - Telomerase inhibition as cancer therapy JO - Cancer Lett VL - 194 ID - Saretzki2003 ER - TY - JOUR AU - Saretzki, G. AU - von Zglinicki, T. PY - 2003 DA - 2003// TI - Telomerase as a promising target for human cancer gene therapy JO - Drugs Today (Barc) VL - 39 ID - Saretzki2003 ER - TY - JOUR AU - Blasco, M. A. PY - 2003 DA - 2003// TI - Telomeres and cancer: a tale with many endings JO - Curr Opin Genet Dev VL - 13 ID - Blasco2003 ER - TY - JOUR AU - Rezler, E. M. AU - Bearss, D. J. AU - Hurley, L. H. PY - 2002 DA - 2002// TI - Telomeres and telomerases as drug targets JO - Curr Opin Pharmacol VL - 2 ID - Rezler2002 ER - TY - JOUR AU - Sun, D. AU - Hurley, L. H. PY - 2001 DA - 2001// TI - Targeting telomeres and telomerase JO - Methods Enzymol VL - 340 ID - Sun2001 ER - TY - JOUR AU - Saretzki, G. AU - Ludwig, A. AU - von Zglinicki, T. AU - Runnebaum, I. B. PY - 2001 DA - 2001// TI - Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells JO - Cancer Gene Ther VL - 8 ID - Saretzki2001 ER - TY - JOUR AU - Shammas, M. A. AU - Shmookler Reis, R. J. AU - Akiyama, M. AU - Koley, H. AU - Chauhan, D. AU - Hideshima, T. AU - Goyal, R. K. AU - Hurley, L. H. AU - Anderson, K. C. AU - Munshi, N. C. PY - 2003 DA - 2003// TI - Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma JO - Mol Cancer Ther VL - 2 ID - Shammas2003 ER - TY - JOUR AU - Tanious, F. A. AU - Jenkins, T. C. AU - Neidle, S. AU - Wilson, W. D. PY - 1992 DA - 1992// TI - Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs JO - Biochemistry VL - 31 ID - Tanious1992 ER - TY - JOUR AU - Sun, D. AU - Thompson, B. AU - Cathers, B. E. AU - Salazar, M. AU - Kerwin, S. M. AU - Trent, J. O. AU - Jenkins, T. C. AU - Neidle, S. AU - Hurley, L. H. PY - 1997 DA - 1997// TI - Inhibition of human telomerase by a G-quadruplex-interactive compound JO - J Med Chem VL - 40 ID - Sun1997 ER - TY - JOUR AU - Harrison, R. J. AU - Cuesta, J. AU - Chessari, G. AU - Read, M. A. AU - Basra, S. K. AU - Reszka, A. P. AU - Morrell, J. AU - Gowan, S. M. AU - Incles, C. M. AU - Tanious, F. A. AU - Wilson, W. D. AU - Kelland, L. R. AU - Neidle, S. PY - 2003 DA - 2003// TI - Trisubstituted acridine derivatives as potent and selective telomerase inhibitors JO - J Med Chem VL - 46 ID - Harrison2003 ER - TY - JOUR AU - Gowan, S. M. AU - Harrison, J. R. AU - Patterson, L. AU - Valenti, M. AU - Read, M. A. AU - Neidle, S. AU - Kelland, L. R. PY - 2002 DA - 2002// TI - A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity JO - Mol Pharmacol VL - 61 ID - Gowan2002 ER - TY - JOUR AU - Anantha, N. V. AU - Azam, M. AU - Sheardy, R. D. PY - 1998 DA - 1998// TI - Porphyrin binding to quadrupled T4G4 JO - Biochemistry VL - 37 ID - Anantha1998 ER - TY - JOUR AU - Han, H. AU - Langley, D. R. AU - Rangan, A. AU - Hurley, L. H. PY - 2001 DA - 2001// TI - Selective interactions of cationic porphyrins with G-quadruplex structures JO - J Am Chem Soc VL - 123 ID - Han2001 ER - TY - JOUR AU - Han, H. AU - Cliff, C. L. AU - Hurley, L. H. PY - 1999 DA - 1999// TI - Accelerated assembly of G-quadruplex structures by a small molecule JO - Biochemistry VL - 38 ID - Han1999 ER - TY - JOUR AU - Gazin, C. AU - Dupont de Dinechin, S. AU - Hampe, A. AU - Masson, J. M. AU - Martin, P. AU - Stehelin, D. AU - Galibert, F. PY - 1984 DA - 1984// TI - Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon JO - Embo J VL - 3 ID - Gazin1984 ER - TY - JOUR AU - Cooney, M. AU - Czernuszewicz, G. AU - Postel, E. H. AU - Flint, S. J. AU - Hogan, M. E. PY - 1988 DA - 1988// TI - Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro JO - Science VL - 241 ID - Cooney1988 ER - TY - JOUR AU - Postel, E. H. AU - Flint, S. J. AU - Kessler, D. J. AU - Hogan, M. E. PY - 1991 DA - 1991// TI - Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels JO - Proc Natl Acad Sci U S A VL - 88 ID - Postel1991 ER - TY - JOUR AU - Kang, C. H. AU - Berger, I. AU - Lockshin, C. AU - Ratliff, R. AU - Moyzis, R. AU - Rich, A. PY - 1994 DA - 1994// TI - Crystal structure of intercalated four-stranded d(C3T) at 1.4 A resolution JO - Proc Natl Acad Sci U S A VL - 91 ID - Kang1994 ER - TY - JOUR AU - Gehring, K. AU - Leroy, J. L. AU - Gueron, M. PY - 1993 DA - 1993// TI - A tetrameric DNA structure with protonated cytosine.cytosine base pairs JO - Nature VL - 363 ID - Gehring1993 ER - TY - JOUR AU - Chen, L. AU - Cai, L. AU - Zhang, X. AU - Rich, A. PY - 1994 DA - 1994// TI - Crystal structure of a four-stranded intercalated DNA: d(C4) JO - Biochemistry VL - 33 ID - Chen1994 ER - TY - JOUR AU - Grand, C. L. AU - Han, H. AU - Munoz, R. M. AU - Weitman, S. AU - Von Hoff, D. D. AU - Hurley, L. H. AU - Bearss, D. J. PY - 2002 DA - 2002// TI - The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo JO - Mol Cancer Ther VL - 1 ID - Grand2002 ER - TY - JOUR AU - Wadkins, R. M. PY - 2000 DA - 2000// TI - Targeting DNA secondary structures JO - Curr Med Chem VL - 7 ID - Wadkins2000 ER - TY - JOUR AU - Wadkins, R. M. AU - Tung, C. S. AU - Vallone, P. M. AU - Benight, A. S. PY - 2000 DA - 2000// TI - The role of the loop in binding of an actinomycin D analog to hairpins formed by single-stranded DNA JO - Arch Biochem Biophys VL - 384 ID - Wadkins2000 ER - TY - JOUR AU - Chen, F. M. AU - Sha, F. AU - Chin, K. H. AU - Chou, S. H. PY - 2003 DA - 2003// TI - Unique actinomycin D binding to self-complementary d(CXYGGCCY'X'G) sequences: duplex disruption and binding to a nominally base-paired hairpin JO - Nucleic Acids Res VL - 31 ID - Chen2003 ER - TY - JOUR AU - Eichman, B. F. AU - Vargason, J. M. AU - Mooers, B. H. AU - Ho, P. S. PY - 2000 DA - 2000// TI - The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions JO - Proc Natl Acad Sci U S A VL - 97 ID - Eichman2000 ER - TY - JOUR AU - West, K. L. AU - Austin, C. A. PY - 1999 DA - 1999// TI - Human DNA topoisomerase IIbeta binds and cleaves four-way junction DNA in vitro JO - Nucleic Acids Res VL - 27 ID - West1999 ER - TY - JOUR AU - Zhong, M. AU - Rashes, M. S. AU - Marky, L. A. AU - Kallenbach, N. R. PY - 1992 DA - 1992// TI - T-T base mismatches enhance drug binding at the branch site in a four-arm DNA junction JO - Biochemistry VL - 31 ID - Zhong1992 ER - TY - JOUR AU - Yang, X. L. AU - Robinson, H. AU - Gao, Y. G. AU - Wang, A. H. PY - 2000 DA - 2000// TI - Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms JO - Biochemistry VL - 39 ID - Yang2000 ER - TY - JOUR AU - Thorpe, J. H. AU - Hobbs, J. R. AU - Todd, A. K. AU - Denny, W. A. AU - Charlton, P. AU - Cardin, C. J. PY - 2000 DA - 2000// TI - Guanine specific binding at a DNA junction formed by d[CG(5-BrU)ACG](2) with a topoisomerase poison in the presence of Co(2+) ions JO - Biochemistry VL - 39 ID - Thorpe2000 ER - TY - JOUR AU - Adams, A. AU - Guss, J. M. AU - Collyer, C. A. AU - Denny, W. A. AU - Wakelin, L. P. PY - 2000 DA - 2000// TI - A novel form of intercalation involving four DNA duplexes in an acridine-4-carboxamide complex of d(CGTACG)(2) JO - Nucleic Acids Res VL - 28 ID - Adams2000 ER - TY - JOUR AU - Teixeira, S. C. AU - Thorpe, J. H. AU - Todd, A. K. AU - Powell, H. R. AU - Adams, A. AU - Wakelin, L. P. AU - Denny, W. A. AU - Cardin, C. J. PY - 2002 DA - 2002// TI - Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex JO - J Mol Biol VL - 323 ID - Teixeira2002 ER - TY - JOUR AU - Fox, K. R. PY - 2000 DA - 2000// TI - Targeting DNA with triplexes JO - Curr Med Chem VL - 7 ID - Fox2000 ER - TY - JOUR AU - Sarkar, P. S. AU - Brahmachari, S. K. PY - 1992 DA - 1992// TI - Intramolecular triplex potential sequence within a gene down regulates its expression in vivo JO - Nucleic Acids Res VL - 20 ID - Sarkar1992 ER - TY - JOUR AU - Duval-Valentin, G. AU - de Bizemont, T. AU - Takasugi, M. AU - Mergny, J. L. AU - Bisagni, E. AU - Helene, C. PY - 1995 DA - 1995// TI - Triple-helix specific ligands stabilize H-DNA conformation JO - J Mol Biol VL - 247 ID - Duval-Valentin1995 ER - TY - JOUR AU - Sehlstedt, U. AU - Aich, P. AU - Bergman, J. AU - Vallberg, H. AU - Norden, B. AU - Graslund, A. PY - 1998 DA - 1998// TI - Interactions of the antiviral quinoxaline derivative 9-OH-B220 [2, 3-dimethyl-6-(dimethylaminoethyl)- 9-hydroxy-6H-indolo-[2, 3-b]quinoxaline] with duplex and triplex forms of synthetic DNA and RNA JO - J Mol Biol VL - 278 ID - Sehlstedt1998 ER - TY - JOUR AU - Arya, D. P. AU - Micovic, L. AU - Charles, I. AU - Coffee, R. L. ,. J. r. AU - Willis, B. AU - Xue, L. PY - 2003 DA - 2003// TI - Neomycin binding to Watson-Hoogsteen (W-H) DNA triplex groove: a model JO - J Am Chem Soc VL - 125 ID - Arya2003 ER - TY - JOUR AU - Topcu, Z. PY - 2001 DA - 2001// TI - DNA topoisomerases as targets for anticancer drugs JO - J Clin Pharm Ther VL - 26 ID - Topcu2001 ER - TY - JOUR AU - Wall, M. E. AU - Wani, M. C. PY - 1996 DA - 1996// TI - Camptothecin. Discovery to clinic JO - Ann N Y Acad Sci VL - 803 ID - Wall1996 ER - TY - JOUR AU - Hsiang, Y. H. AU - Liu, L. F. PY - 1988 DA - 1988// TI - Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin JO - Cancer Res VL - 48 ID - Hsiang1988 ER - TY - JOUR AU - Berger, J. M. AU - Gamblin, S. J. AU - Harrison, S. C. AU - Wang, J. C. PY - 1996 DA - 1996// TI - Structure and mechanism of DNA topoisomerase II JO - Nature VL - 379 ID - Berger1996 ER - TY - JOUR AU - Larsen, A. K. AU - Escargueil, A. E. AU - Skladanowski, A. PY - 2003 DA - 2003// TI - Catalytic topoisomerase II inhibitors in cancer therapy JO - Pharmacol Ther VL - 99 ID - Larsen2003 ER - TY - JOUR AU - Hsiang, Y. H. AU - Wu, H. Y. AU - Liu, L. F. PY - 1988 DA - 1988// TI - Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells JO - Cancer Res VL - 48 ID - Hsiang1988 ER - TY - JOUR AU - Prosperi, E. AU - Negri, C. AU - Marchese, G. AU - Ricotti, G. C. PY - 1994 DA - 1994// TI - Expression of the 170-kDa and 180-kDa isoforms of DNA topoisomerase II in resting and proliferating human lymphocytes JO - Cell Prolif VL - 27 ID - Prosperi1994 ER - TY - JOUR AU - Del Bino, G. AU - Lassota, P. AU - Darzynkiewicz, Z. PY - 1991 DA - 1991// TI - The S-phase cytotoxicity of camptothecin JO - Exp Cell Res VL - 193 ID - Del Bino1991 ER - TY - JOUR AU - Goossens, J. F. AU - Henichart, J. P. AU - Dassonneville, L. AU - Facompre, M. AU - Bailly, C. PY - 2000 DA - 2000// TI - Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells JO - Eur J Pharm Sci VL - 10 ID - Goossens2000 ER - TY - JOUR AU - Kaufmann, W. K. AU - Boyer, J. C. AU - Estabrooks, L. L. AU - Wilson, S. J. PY - 1991 DA - 1991// TI - Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes JO - Mol Cell Biol VL - 11 ID - Kaufmann1991 ER - TY - JOUR AU - Zhang, H. AU - Wang, J. C. AU - Liu, L. F. PY - 1988 DA - 1988// TI - Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes JO - Proc Natl Acad Sci U S A VL - 85 ID - Zhang1988 ER - TY - JOUR AU - Karpf, A. R. AU - Jones, D. A. PY - 2002 DA - 2002// TI - Reactivating the expression of methylation silenced genes in human cancer JO - Oncogene VL - 21 ID - Karpf2002 ER - TY - JOUR AU - Claus, R. AU - Lubbert, M. PY - 2003 DA - 2003// TI - Epigenetic targets in hematopoietic malignancies JO - Oncogene VL - 22 ID - Claus2003 ER - TY - JOUR AU - Gardiner-Garden, M. AU - Frommer, M. PY - 1987 DA - 1987// TI - CpG islands in vertebrate genomes JO - J Mol Biol VL - 196 ID - Gardiner-Garden1987 ER - TY - JOUR AU - Cross, S. H. AU - Bird, A. P. PY - 1995 DA - 1995// TI - CpG islands and genes JO - Curr Opin Genet Dev VL - 5 ID - Cross1995 ER - TY - JOUR AU - Barlow, D. P. PY - 1995 DA - 1995// TI - Gametic imprinting in mammals JO - Science VL - 270 ID - Barlow1995 ER - TY - JOUR AU - Goto, T. AU - Monk, M. PY - 1998 DA - 1998// TI - Regulation of X-chromosome inactivation in development in mice and humans JO - Microbiol Mol Biol Rev VL - 62 ID - Goto1998 ER - TY - JOUR AU - Jones, P. A. AU - Laird, P. W. PY - 1999 DA - 1999// TI - Cancer epigenetics comes of age JO - Nat Genet VL - 21 ID - Jones1999 ER - TY - JOUR AU - Jones, P. A. AU - Taylor, S. M. PY - 1980 DA - 1980// TI - Cellular differentiation, cytidine analogs and DNA methylation JO - Cell VL - 20 ID - Jones1980 ER - TY - JOUR AU - Bender, C. M. AU - Zingg, J. M. AU - Jones, P. A. PY - 1998 DA - 1998// TI - DNA methylation as a target for drug design JO - Pharm Res VL - 15 ID - Bender1998 ER - TY - JOUR AU - Ferguson, A. T. AU - Vertino, P. M. AU - Spitzner, J. R. AU - Baylin, S. B. AU - Muller, M. T. AU - Davidson, N. E. PY - 1997 DA - 1997// TI - Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells JO - J Biol Chem VL - 272 ID - Ferguson1997 ER - TY - JOUR AU - Leone, G. AU - Voso, M. T. AU - Teofili, L. AU - Lubbert, M. PY - 2003 DA - 2003// TI - Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS JO - Clin Immunol VL - 109 ID - Leone2003 ER - TY - JOUR AU - Leone, G. AU - Teofili, L. AU - Voso, M. T. AU - Lubbert, M. PY - 2002 DA - 2002// TI - DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias JO - Haematologica VL - 87 ID - Leone2002 ER - TY - JOUR AU - Lubbert, M. PY - 2000 DA - 2000// TI - DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action JO - Curr Top Microbiol Immunol VL - 249 ID - Lubbert2000 ER - TY - JOUR AU - Santini, V. AU - Kantarjian, H. M. AU - Issa, J. P. PY - 2001 DA - 2001// TI - Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications JO - Ann Intern Med VL - 134 ID - Santini2001 ER - TY - JOUR AU - Fournel, M. AU - Sapieha, P. AU - Beaulieu, N. AU - Besterman, J. M. AU - MacLeod, A. R. PY - 1999 DA - 1999// TI - Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms JO - J Biol Chem VL - 274 ID - Fournel1999 ER - TY - JOUR AU - Bigey, P. AU - Knox, J. D. AU - Croteau, S. AU - Bhattacharya, S. K. AU - Theberge, J. AU - Szyf, M. PY - 1999 DA - 1999// TI - Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase JO - J Biol Chem VL - 274 ID - Bigey1999 ER - TY - JOUR AU - Yang, X. J. AU - Seto, E. PY - 2003 DA - 2003// TI - Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression JO - Curr Opin Genet Dev VL - 13 ID - Yang2003 ER - TY - JOUR AU - Thiagalingam, S. AU - Cheng, K. H. AU - Lee, H. J. AU - Mineva, N. AU - Thiagalingam, A. AU - Ponte, J. F. PY - 2003 DA - 2003// TI - Histone deacetylases: unique players in shaping the epigenetic histone code JO - Ann N Y Acad Sci VL - 983 ID - Thiagalingam2003 ER - TY - JOUR AU - Fischle, W. AU - Wang, Y. AU - Allis, C. D. PY - 2003 DA - 2003// TI - Histone and chromatin cross-talk JO - Curr Opin Cell Biol VL - 15 ID - Fischle2003 ER - TY - JOUR AU - Grewal, S. I. AU - Moazed, D. PY - 2003 DA - 2003// TI - Heterochromatin and epigenetic control of gene expression JO - Science VL - 301 ID - Grewal2003 ER - TY - JOUR AU - Jaenisch, R. AU - Bird, A. PY - 2003 DA - 2003// TI - Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals JO - Nat Genet VL - 33 Suppl ID - Jaenisch2003 ER - TY - JOUR AU - Deckert, J. AU - Struhl, K. PY - 2002 DA - 2002// TI - Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein JO - Mol Cell Biol VL - 22 ID - Deckert2002 ER - TY - JOUR AU - Moazed, D. PY - 2001 DA - 2001// TI - Common themes in mechanisms of gene silencing JO - Mol Cell VL - 8 ID - Moazed2001 ER - TY - JOUR AU - Henderson, C. AU - Brancolini, C. PY - 2003 DA - 2003// TI - Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype JO - Drug Resist Updat VL - 6 ID - Henderson2003 ER - TY - JOUR AU - Arts, J. AU - de Schepper, S. AU - Van Emelen, K. PY - 2003 DA - 2003// TI - Histone deacetylase inhibitors: from chromatin remodeling to experimental cancer therapeutics JO - Curr Med Chem VL - 10 ID - Arts2003 ER - TY - JOUR AU - De Schepper, S. AU - Bruwiere, H. AU - Verhulst, T. AU - Steller, U. AU - Andries, L. AU - Wouters, W. AU - Janicot, M. AU - Arts, J. AU - Van Heusden, J. PY - 2003 DA - 2003// TI - Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin JO - J Pharmacol Exp Ther VL - 304 ID - De Schepper2003 ER - TY - JOUR AU - Vigushin, D. M. AU - Coombes, R. C. PY - 2002 DA - 2002// TI - Histone deacetylase inhibitors in cancer treatment JO - Anticancer Drugs VL - 13 ID - Vigushin2002 ER - TY - JOUR AU - Kelly, W. K. AU - Richon, V. M. AU - O'Connor, O. AU - Curley, T. AU - MacGregor-Curtelli, B. AU - Tong, W. AU - Klang, M. AU - Schwartz, L. AU - Richardson, S. AU - Rosa, E. AU - Drobnjak, M. AU - Cordon-Cordo, C. AU - Chiao, J. H. AU - Rifkind, R. AU - Marks, P. A. AU - Scher, H. PY - 2003 DA - 2003// TI - Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously JO - Clin Cancer Res VL - 9 ID - Kelly2003 ER - TY - JOUR AU - Marshall, J. L. AU - Rizvi, N. AU - Kauh, J. AU - Dahut, W. AU - Figuera, M. AU - Kang, M. H. AU - Figg, W. D. AU - Wainer, I. AU - Chaissang, C. AU - Li, M. Z. AU - Hawkins, M. J. PY - 2002 DA - 2002// TI - A phase I trial of depsipeptide (FR901228) in patients with advanced cancer JO - J Exp Ther Oncol VL - 2 ID - Marshall2002 ER - TY - JOUR AU - Finnin, M. S. AU - Donigian, J. R. AU - Cohen, A. AU - Richon, V. M. AU - Rifkind, R. A. AU - Marks, P. A. AU - Breslow, R. AU - Pavletich, N. P. PY - 1999 DA - 1999// TI - Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors JO - Nature VL - 401 ID - Finnin1999 ER - TY - JOUR AU - Marks, P. AU - Rifkind, R. A. AU - Richon, V. M. AU - Breslow, R. AU - Miller, T. AU - Kelly, W. K. PY - 2001 DA - 2001// TI - Histone deacetylases and cancer: causes and therapies JO - Nat Rev Cancer VL - 1 ID - Marks2001 ER - TY - JOUR AU - Mitsiades, N. AU - Mitsiades, C. S. AU - Richardson, P. G. AU - McMullan, C. AU - Poulaki, V. AU - Fanourakis, G. AU - Schlossman, R. AU - Chauhan, D. AU - Munshi, N. C. AU - Hideshima, T. AU - Richon, V. M. AU - Marks, P. A. AU - Anderson, K. C. PY - 2003 DA - 2003// TI - Molecular sequelae of histone deacetylase inhibition in human malignant B cells JO - Blood VL - 101 ID - Mitsiades2003 ER - TY - JOUR AU - Mitsiades, C. S. AU - Mitsiades, N. S. AU - McMullan, C. J. AU - Poulaki, V. AU - Shringarpure, R. AU - Hideshima, T. AU - Akiyama, M. AU - Chauhan, D. AU - Munshi, N. AU - Gu, X. AU - Bailey, C. AU - Joseph, M. AU - Libermann, T. A. AU - Richon, V. M. AU - Marks, P. A. AU - Anderson, K. C. PY - 2004 DA - 2004// TI - Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications JO - Proc Natl Acad Sci U S A VL - 101 ID - Mitsiades2004 ER - TY - JOUR AU - Primeau, M. AU - Gagnon, J. AU - Momparler, R. L. PY - 2003 DA - 2003// TI - Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2'-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells JO - Int J Cancer VL - 103 ID - Primeau2003 ER - TY - JOUR AU - Zhu, W. G. AU - Otterson, G. A. PY - 2003 DA - 2003// TI - The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells JO - Curr Med Chem Anti-Canc Agents VL - 3 ID - Zhu2003 ER - TY - JOUR AU - Gagnon, J. AU - Shaker, S. AU - Primeau, M. AU - Hurtubise, A. AU - Momparler, R. L. PY - 2003 DA - 2003// TI - Interaction of 5-aza-2'-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells JO - Anticancer Drugs VL - 14 ID - Gagnon2003 ER - TY - JOUR AU - Yang, L. AU - Mei, Q. AU - Zielinska-Kwiatkowska, A. AU - Matsui, Y. AU - Blackburn, M. L. AU - Benedetti, D. AU - Krumm, A. A. AU - Taborsky, G. J. ,. J. r. AU - Chansky, H. A. PY - 2003 DA - 2003// TI - An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B JO - Biochem J VL - 369 ID - Yang2003 ER - TY - JOUR AU - Zhu, W. G. AU - Lakshmanan, R. R. AU - Beal, M. D. AU - Otterson, G. A. PY - 2001 DA - 2001// TI - DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors JO - Cancer Res VL - 61 ID - Zhu2001 ER - TY - JOUR AU - Rahmani, M. AU - Yu, C. AU - Dai, Y. AU - Reese, E. AU - Ahmed, W. AU - Dent, P. AU - Grant, S. PY - 2003 DA - 2003// TI - Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells JO - Cancer Res VL - 63 ID - Rahmani2003 ER - TY - JOUR AU - Ming, L. J. PY - 2003 DA - 2003// TI - Structure and function of "metalloantibiotics" JO - Med Res Rev VL - 23 ID - Ming2003 ER - TY - JOUR AU - Malina, J. AU - Kasparkova, J. AU - Natile, G. AU - Brabec, V. PY - 2002 DA - 2002// TI - Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts JO - Chem Biol VL - 9 ID - Malina2002 ER - TY - JOUR AU - Cohen, S. M. AU - Mikata, Y. AU - He, Q. AU - Lippard, S. J. PY - 2000 DA - 2000// TI - HMG-domain protein recognition of cisplatin 1,2-intrastrand d(GpG) cross-links in purine-rich sequence contexts JO - Biochemistry VL - 39 ID - Cohen2000 ER - TY - JOUR AU - Pil, P. M. AU - Lippard, S. J. PY - 1992 DA - 1992// TI - Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin JO - Science VL - 256 ID - Pil1992 ER - TY - JOUR AU - Siddik, Z. H. PY - 2003 DA - 2003// TI - Cisplatin: mode of cytotoxic action and molecular basis of resistance JO - Oncogene VL - 22 ID - Siddik2003 ER - TY - JOUR AU - Wei, M. AU - Cohen, S. M. AU - Silverman, A. P. AU - Lippard, S. J. PY - 2001 DA - 2001// TI - Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins JO - J Biol Chem VL - 276 ID - Wei2001 ER - TY - JOUR AU - Vichi, P. AU - Coin, F. AU - Renaud, J. P. AU - Vermeulen, W. AU - Hoeijmakers, J. H. AU - Moras, D. AU - Egly, J. M. PY - 1997 DA - 1997// TI - Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP JO - Embo J VL - 16 ID - Vichi1997 ER - TY - JOUR AU - Hoffmann, J. S. AU - Locker, D. AU - Villani, G. AU - Leng, M. PY - 1997 DA - 1997// TI - HMG1 protein inhibits the translesion synthesis of the major DNA cisplatin adduct by cell extracts JO - J Mol Biol VL - 270 ID - Hoffmann1997 ER - TY - JOUR AU - He, Q. AU - Liang, C. H. AU - Lippard, S. J. PY - 2000 DA - 2000// TI - Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin JO - Proc Natl Acad Sci U S A VL - 97 ID - He2000 ER - TY - JOUR AU - Huang, J. C. AU - Zamble, D. B. AU - Reardon, J. T. AU - Lippard, S. J. AU - Sancar, A. PY - 1994 DA - 1994// TI - HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease JO - Proc Natl Acad Sci U S A VL - 91 ID - Huang1994 ER - TY - JOUR AU - Zamble, D. B. AU - Mu, D. AU - Reardon, J. T. AU - Sancar, A. AU - Lippard, S. J. PY - 1996 DA - 1996// TI - Repair of cisplatin--DNA adducts by the mammalian excision nuclease JO - Biochemistry VL - 35 ID - Zamble1996 ER - TY - JOUR AU - Siddik, Z. H. PY - 2002 DA - 2002// TI - Biochemical and molecular mechanisms of cisplatin resistance JO - Cancer Treat Res VL - 112 ID - Siddik2002 ER - TY - JOUR AU - Boulikas, T. AU - Vougiouka, M. PY - 2003 DA - 2003// TI - Cisplatin and platinum drugs at the molecular level. (Review) JO - Oncol Rep VL - 10 ID - Boulikas2003 ER - TY - JOUR AU - Roskoski, R. ,. J. r. PY - 2003 DA - 2003// TI - STI-571: an anticancer protein-tyrosine kinase inhibitor JO - Biochem Biophys Res Commun VL - 309 ID - Roskoski2003 ER - TY - JOUR AU - Denny, W. A. PY - 2001 DA - 2001// TI - Prodrug strategies in cancer therapy JO - Eur J Med Chem VL - 36 ID - Denny2001 ER -