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Table 1 Cytogenetic analysis of mouse metaphase II oocytes following in vitro exposure to the proteasome inhibitor MG-132

From: MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes

MG-132 (mcg/ml) No. cells analyzed No. MI oocytes (%) No. MII oocytes (%) No. premature centromere separation (%) No. single chromatids (%) No. haploid (%) No. hypoploid (%) No. hyperploid (%)
Control 130 13 (10.0)a 117 (90.0) 43 (36.8)a 1 (0.9)a 101 (86.3) 16 (13.7) -0-a
5.0 158 19 (12.0)a 139 (88.0) 38 (27.3) 3 (2.2)a,b 121 (87.1) 18 (12.9) -0-a
7.5 191 26 (13.6)a 165 (86.4) 44 (26.7) 11 (6.7)b 142 (86.1) 18 (10.9) 5 (3.0)b
10.0 125 53 (42.4)b 72 (57.6) 13 (18.1)b 11 (15.3)c 62 (86.1) 3 (4.2) 7 (9.7)c
  1. Different superscripts among proportions in the same column indicate significant (P < 0.01) differences.