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Figure 1 | Cell & Chromosome

Figure 1

From: MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes

Figure 1

Cytogenetic analysis of mouse oocytes following in vitro exposure to MG-132, chromosome configurations are shown. (A) metaphase II oocyte, normal, n = 20 dyads. (B) metaphase I oocyte, normal, N = 20 tetrads. (C) metaphase II oocyte, hypoploid, premature centromere separation (incomplete), n = 19 1/2 (10 dyads and 19 chromatids), arrow points to one of the 19 single, unpaired chromatids. (D) metaphase II oocyte, hyperploid, n= 22 dyads. (E) metaphase II oocyte, hyperploid, single-unpaired chromatid, n = 20 1/2 (20 dyads and one single, unpaired chromatid indicated by arrow). (F) metaphase I oocyte, diffuse chromatin, N= 20 probable tetrads. (G) metaphase I oocyte, homologue separation, N= 20 (17 tetrads and 6 dyads), arrow points to one of the 6 dyads. (H) metaphase I oocyte, homologue separation, N= 19 1/2 (16 tetrads and 7 dyads).

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Cell & Chromosome

ISSN: 1475-9268